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Effectiveness of acupuncture for vascular cognitive impairment no dementia: a randomized controlled trial.
- Source :
- Clinical Rehabilitation; Apr2019, Vol. 33 Issue 4, p642-652, 11p, 1 Diagram, 4 Charts
- Publication Year :
- 2019
-
Abstract
- Objective: To evaluate the effectiveness of acupuncture in patients with vascular cognitive impairment no dementia (VCIND) in comparison with citicoline, an agent for cognitive disturbances associated with chronic cerebral disorders. Design: A randomized controlled multicenter trial. Setting: In three hospitals in Beijing, China. Subjects: A total of 216 patients with VCIND were recruited. Interventions: Patients with VCIND (mean age of 65.4 years) were randomized to receive acupuncture (two sessions per week) or oral citicoline (100 mg three times daily) over three months. Main measures: The primary outcome was the change from baseline to three months in cognitive symptom, measured by Alzheimer's disease Assessment Scale, cognitive subscale (ADAS-cog). Secondary outcomes included changes from baseline to six months in ADAS-cog, executive function measured by the Clock Drawing Test (CDT), and functional disability measured by the Ability of Daily Living (ADL) scale at three and six months. Results: At three months, the acupuncture group had a greater decrease in mean ADAS-cog score (−2.33 ± 0.31) than the citicoline group (−1.38 ± 0.34) with a mean difference of −0.95 (95% CI, −1.84 to −0.07, P = 0.035). The mean change from baseline to six months in ADAS-cog also significantly favored acupuncture treatments (acupuncture change −2.61 vs citicoline −1.25, difference: −1.36 points; 95% CI, −2.20 to −0.51; P = 0.002). There was no difference between the two groups on CDT and ADL scores at either time point. Conclusion: Compared with citicoline, acupuncture has comparable and even superior efficacy with improved cognitive and daily living performance as a complementary and alternative medicine treatment for VCIND. [ABSTRACT FROM AUTHOR]
- Subjects :
- NUCLEOTIDES
COGNITION disorders treatment
ACUPUNCTURE
ANALYSIS of covariance
CEREBROVASCULAR disease
CHI-squared test
CONFIDENCE intervals
FISHER exact test
MEDICAL cooperation
PSYCHOLOGICAL tests
PSYCHOMETRICS
QUESTIONNAIRES
RESEARCH
RESEARCH funding
STROKE
T-test (Statistics)
ACTIVITIES of daily living
VASCULAR dementia
RANDOMIZED controlled trials
TREATMENT effectiveness
INTER-observer reliability
EXECUTIVE function
DATA analysis software
DESCRIPTIVE statistics
MANN Whitney U Test
DISEASE complications
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 02692155
- Volume :
- 33
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Clinical Rehabilitation
- Publication Type :
- Academic Journal
- Accession number :
- 135484280
- Full Text :
- https://doi.org/10.1177/0269215518819050