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Integrated stress response and immune cell infiltration in an ibrutinib‐refractory mantle cell lymphoma patient following ONC201 treatment.

Authors :
Romaguera, Jorge E.
Lee, Hun J.
Tarapore, Rohinton
Prabhu, Varun
Allen, Joshua
Schalop, Lee
Zloza, Andrew
Ok, Chi Y.
Sadimin, Evita T.
Schenkel, Jason
Badillo, Maria
Wang, Michael
Source :
British Journal of Haematology; Apr2019, Vol. 185 Issue 1, p133-136, 4p, 1 Diagram, 1 Graph
Publication Year :
2019

Abstract

The article discusses the mantle cell lymphoma (MCL) which is an incurable subtype of non-Hodgkin lymphoma that can be treated with ONC201. It states that Bruton tyrosine kinase (BTK) inhibitor ibrutinib ahieves 68% overall response rate in relapsed/refractory MCL patients following an ONC201 treatment.

Details

Language :
English
ISSN :
00071048
Volume :
185
Issue :
1
Database :
Complementary Index
Journal :
British Journal of Haematology
Publication Type :
Academic Journal
Accession number :
135666085
Full Text :
https://doi.org/10.1111/bjh.15271