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A Bioelectronic Platform Modulates pH in Biologically Relevant Conditions.
- Source :
- Advanced Science; 4/3/2019, Vol. 6 Issue 7, pN.PAG-N.PAG, 1p
- Publication Year :
- 2019
-
Abstract
- Bioelectronic devices that modulate pH can affect critical biological processes including enzymatic activity, oxidative phosphorylation, and neuronal excitability. A major challenge in controlling pH is the high buffering capacity of many biological media. To overcome this challenge, devices need to be able to store and deliver a large number of protons on demand. Here, a bioelectronic modulator that controls pH using palladium nanoparticles contacts with high surface area as a proton storage medium is developed. Reversible electronically triggered acidosis (low pH) and alkalosis (high pH) in physiologically relevant buffer conditions are achieved. As a proof of principle, this new platform is used to control the degradation and fluorescence of acid sensitive polymeric microparticles loaded with a pH sensitive fluorescent dye. A bioelectronic modulator controls pH using palladium nanoparticle contacts as a proton storage medium. This powerful tool achieves reversible electronically triggered acidosis and alkalosis in physiologically relevant buffer conditions. [ABSTRACT FROM AUTHOR]
- Subjects :
- PALLADIUM
BIOELECTRONICS
PH standards
OXIDATIVE phosphorylation
ALKALOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 21983844
- Volume :
- 6
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Advanced Science
- Publication Type :
- Academic Journal
- Accession number :
- 135709829
- Full Text :
- https://doi.org/10.1002/advs.201800935