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Mechanisms of pathogenesis: differences amongst Leishmania species.
- Source :
- Transactions of the Royal Society of Tropical Medicine & Hygiene; 2002 Supplement, Vol. 96, pS3-S7, 5p
- Publication Year :
- 2002
-
Abstract
- One of the features of the genus Leishmania is the diversity of tropism/disease resulting from infection. With notable exceptions, the form (visceral, cutaneous, diffuse cutaneous, mucocutaneous) and severity of disease is a function of the infecting Leishmania species together with host genetics and consequent inflammatory and immune responses. It has become evident from genetic and immunological studies using the murine model that the various members of the genus Leishmania differ in aspects of their 'approach' to the host immune system. We are just beginning to appreciate the complexities of these interactions, which have import for the development of a vaccine against leishmaniasis. In this paper, what is currently understood concerning the mechanisms of leishmanial pathogenesis (based upon studies employing the murine model) is briefly summarized. [ABSTRACT FROM AUTHOR]
- Subjects :
- LEISHMANIA
SPECIES
IMMUNE response
IMMUNE system
LEISHMANIASIS
Subjects
Details
- Language :
- English
- ISSN :
- 00359203
- Volume :
- 96
- Database :
- Complementary Index
- Journal :
- Transactions of the Royal Society of Tropical Medicine & Hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 135998380
- Full Text :
- https://doi.org/10.1016/S0035-9203(02)90044-1