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Adalimumab in Active and Inactive, Non-Infectious Uveitis: Global Results from the VISUAL I and VISUAL II Trials.
- Source :
- Ocular Immunology & Inflammation; 2019, Vol. 27 Issue 1, p40-50, 11p
- Publication Year :
- 2019
-
Abstract
- <bold>Purpose: </bold>Report global adalimumab safety and efficacy outcomes in patients with non-infectious uveitis.<bold>Methods: </bold>Adults with non-infectious intermediate, posterior, or panuveitis were randomized 1:1 to receive placebo or adalimumab in the VISUAL I (active uveitis) or VISUAL II (inactive uveitis) trials. Integrated global and Japan substudy results are reported. The primary endpoint was time to treatment failure (TF).<bold>Results: </bold>In the integrated studies, TF risk was significantly reduced (hazard ratio [95% CI]) with adalimumab versus placebo (VISUAL I: HR = 0.56 [0.40-0.76], p < 0.001; VISUAL II: HR = 0.52 [0.37-0.74], p < 0.001). In Japan substudies, no consistent trends were observed between groups (VISUAL I: HR = 1.20 [0.41-3.54]; VISUAL II: HR = 0.45 [0.20-1.03]). Adverse event rates were similar between treatment groups in both studies (854 to 1063 events/100 participant-years).<bold>Conclusions: </bold>Adalimumab lowered time to TF versus placebo in the integrated population; no consistent trends were observed in Japan substudies. Safety results were consistent between studies. [ABSTRACT FROM AUTHOR]
- Subjects :
- UVEITIS
ADALIMUMAB
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 09273948
- Volume :
- 27
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Ocular Immunology & Inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 136150336
- Full Text :
- https://doi.org/10.1080/09273948.2018.1491605