Gastrodia elata Blume-Derived Vanillyl Alcohol Suppresses Amyloid β-Peptide-Induced Caspase Activation in SH-SY5Y Cells.

In this study, we isolated and characterized Gastrodia elata Blume-derived vanillyl alcohol (GEVA) to elucidate biomedical efficacies in improving memory. Acetylcholinesterase (AChE) inhibition assay revealed that GEVA has an inhibitory activity against AChE. In addition, GEVA inhibited amyloid β-peptide (Aβ_25–35)-induced caspase (CASP)-3/7 activities in SH-SY5Y cells. Therefore, this work indicates that GEVA may be effective in preventing memory loss. [ABSTRACT FROM AUTHOR]