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Divergolides T–W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete Streptomyces sp. KFD18.
- Source :
- Marine Drugs; Apr2019, Vol. 17 Issue 4, p219, 1p
- Publication Year :
- 2019
-
Abstract
- Four new ansamycins, named divergolides T–W (1–4), along with two known analogs were isolated from the fermentation broth of the mangrove-derived actinomycete Streptomyces sp. KFD18. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were determined by spectroscopic data and single-crystal X-ray diffraction analysis. Compounds 1–4 showed cytotoxic activity against the human gastric cancer cell line SGC-7901, the human leukemic cell line K562, the HeLa cell line, and the human lung carcinoma cell line A549, with 1 being the most active while compounds 5 and 6 were inactive against all the tested cell lines. Compounds 1 and 3 showed very potent and specific cytotoxic activities (IC<subscript>50</subscript> 2.8 and 4.7 µM, respectively) against the SGC-7901 cells. Further, the apoptosis-inducing effect of 1 and 3 against SGC-7901 cells was demonstrated by two kinds of staining methods for the first time. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16603397
- Volume :
- 17
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Marine Drugs
- Publication Type :
- Academic Journal
- Accession number :
- 136163737
- Full Text :
- https://doi.org/10.3390/md17040219