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Serum hepcidin level and rheumatoid arthritis disease activity.
- Source :
- European Journal of Rheumatology; Apr2019, Vol. 6 Issue 2, p76-80, 5p
- Publication Year :
- 2019
-
Abstract
- Objective: The present study aimed to determine the relationship between the serum hepcidin level and disease activity in patients with rheumatoid arthritis (RA). Methods: This study was conducted on 80 patients with RA (36 cases with anemia of chronic disease [ACD] and 44 patients without ACD). Disease activity was measured by the 28-joint Disease Activity Score based on the erythrocyte sedimentation rate (DAS28-ESR). According to the DAS28-ESR score, 52 and 28 cases were categorized as inactive to moderately active RA (DAS28-ESR=5.1) and highly active RA (DAS28-ESR>5.1), respectively. In addition, the serum hepcidin level was evaluated in all patients to determine its correlation with the DAS28-ESR score. Results: There was no significant difference between the RA with ACD and RA without ACD groups in terms of the median (interquartile range) hepcidin level (1207 [985.2] vs. 923.8 [677.3] ng/mL; P=0.57). Likewise, no significant difference was observed between the active RA and inactive to moderately active RA groups in this regard (1131.8 [991.3] vs. 1090.9 [631.4] ng/mL; P=0.53). Conclusion: Hepcidin has no association with disease activity in RA. Therefore, it is not necessary to measure hepcidin to determine the RA activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- RHEUMATOID arthritis
BLOOD sedimentation
HEPCIDIN
SERUM
Subjects
Details
- Language :
- English
- ISSN :
- 21484279
- Volume :
- 6
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- European Journal of Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 136169481
- Full Text :
- https://doi.org/10.5152/eurjrheum.2018.18114