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Systemic immune response to oral colonization.
- Source :
- Journal of Periodontal Research; 1982, Vol. 17 Issue 3, p237-246, 10p
- Publication Year :
- 1982
-
Abstract
- The principal aim of this work was to analyze the host systemic immune response to an oral infection of <em>A. viscosus</em> T14V. Previous work had established a Balb/c mouse model for <em>A. viscosus</em> T14V oral infection. Animals were infected and the splenocyte response to <em>A. viscosus </em>T14V antigens, LPS, and Con A were assessed in the lymphoblast assay. Splenocytes from mice infected with <em>A. viscosus</em> T14V exhibited an altered response pattern to the antigens and mitogens. The responses were enhanced or suppressed when compared to the uninfected control splenocyte response. The effluent cells from a nylon wool column were unresponsive to <em>A. viscosus</em> antigens but LPS did respond to Con A. This response pattern was true for splenocytes from infected and uninfected animals. These results suggest that <em>A. viscosus</em> T14V is a potent immunomodulater when analyzed within the BaIb/c mouse model system. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNITY
IMMUNOGLOBULINS
LABORATORY rats
ANTIGENS
BIOLOGICAL assay
MITOGENS
Subjects
Details
- Language :
- English
- ISSN :
- 00223484
- Volume :
- 17
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Periodontal Research
- Publication Type :
- Academic Journal
- Accession number :
- 13618701
- Full Text :
- https://doi.org/10.1111/j.1600-0765.1982.tb01150.x