Angina bullosa haemorrhagica‐like lesions in pemphigus vulgaris.

Background/Objectives: The aim of this study was to describe a previously unreported association of oral pemphigus vulgaris with short‐lived blood‐filled painless blisters resembling angina bullosa haemorrhagica (ABH). Methods: A cross‐sectional study of consecutive patients with Pemphigus vulgaris. All patients were examined for the presence of ABH‐like lesions, and demographic, clinical and histopathological data were collected. Histopathological examination was performed when feasible. Results: A total of 318 with pemphigus vulgaris were included (63.5% female, mean age: 46 years). ABH‐like lesions were present in 82 (25.8%) patients, commonly observed in the buccal mucosa (47, 57.3%) followed by the palate (15, 18.3%). All patients had normal platelet counts with no evidence of bleeding diathesis. Biopsies of the ABH‐like lesions showed suprabasal clefts in four of six samples. ABH‐like lesions were significantly associated with partial remission of pemphigus vulgaris (47.5%, P = 0.002) and the use of intraoral steroids (P = 0.001, odds ratio: 5.9 [95% confidence interval: 2.5–13.6]). Conclusion: ABH‐like lesions may represent a transient or abortive form of oral pemphigus vulgaris and tend to have a benign and self‐limiting nature. [ABSTRACT FROM AUTHOR]