Prevalence of acute kidney injury in patients treated with intravenous colistin.

Objective: To determine prevalence of acute kidney injury in patients treated with intravenous colistin. Study design: Cross sectional study. Study settings & duration: Study was conducted at Department of Medicine, King Salman Armed Forces Hospital, Tabuk, Kingdom of Saudi Arabia. Study duration was 6 months (June 2017-November 2017). Material & methods: Sample size of 147 patients was calculated using WHO calculator. Patients were selected using non probability consecutive sampling. Patients received intravenous colistin, were undergone through venous blood samples of creatinine. Patients with creatinine >2mg/dl were diagnosed with acute kidney injury. SPSS soft ware was used for data analysis. Descriptive and inferential statistics were calculated. Chi-square test was applied with p-value =0.05 significant. Results: Total 147 patients were included in study. There were 94(64%) female and 53(36%) males. Mean age of patients was 55±2.4 SD. Among all the patients 147 (100%), 20(14%) patients are at risk of acute kindney injury (AKI), 63(43%) had acute kindney injury while 5(3%) were diagnosed with kidney failure and 59(40%) remained intact with acute kindney injury diagnosis. Males, 40-80 years age group and BMI>30 kg/m2 had high proportion of acute kidney injury (p<0.05). Conclusion: Prevalence of acute kidney injury following colistin administration is very high as compare to previous thought. Further evidence is required for service planning and provision of information to clinicians to prevent deterioration of renal function. [ABSTRACT FROM AUTHOR]