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Pyrimidine 2,4-Diones in the Design of New HIV RT Inhibitors.
- Source :
- Molecules; May2019, Vol. 24 Issue 9, p1718, 1p, 7 Diagrams, 3 Charts
- Publication Year :
- 2019
-
Abstract
- The pyrimidine nucleus is a versatile core in the development of antiretroviral agents. On this basis, a series of pyrimidine-2,4-diones linked to an isoxazolidine nucleus have been synthesized and tested as nucleoside analogs, endowed with potential anti-HIV (human immunodeficiency virus) activity. Compounds 6a–c, characterized by the presence of an ethereal group at C-3, show HIV reverse transcriptase (RT) inhibitor activity in the nanomolar range as well as HIV-infection inhibitor activity in the low micromolar with no toxicity. In the same context, compound 7b shows only a negligible inhibition of RT HIV. [ABSTRACT FROM AUTHOR]
- Subjects :
- PYRIMIDINES
HIV infections
ANTIRETROVIRAL agents
T cells
DRUG resistance
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 24
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 136449502
- Full Text :
- https://doi.org/10.3390/molecules24091718