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In vivo study of mPEG–PCL as a nanocarriers for anti-inflammatory drug delivery of simvastatin.

Authors :
Zamani, Mostafa
Shirinzadeh, Amin
Aghajanzadeh, Mozhgan
Andalib, Sina
Danafar, Hossein
Source :
Pharmaceutical Development & Technology; Jul2019, Vol. 24 Issue 6, p663-670, 8p
Publication Year :
2019

Abstract

Purpose: In this study, methoxy poly (ethylene glycol)-poly (ε-caprolactone) (mPEG–PCL) di-block copolymers were synthesized. The purpose of this work is to investigate the in vivo anti-inflammatory effects of simvastatin-loaded micelles. Methods: The structure of synthesized copolymers was characterized by using HNMR, FTIR, and GPC techniques. Simvastatin was encapsulated in micelles through a single-step nano-precipitation method, leading to the formation of simvastatin-loaded mPEG–PCL (simvastatin-mPEG–PCL) micelles. In this study, the anti-inflammatory effects of simvastatin/mPEG–PCL micelles versus indomethacin were investigated in acute inflammation-induced rats. The paw edema thickness was measured 1, 2, 3, and 4 h after injection of formulation. The inhibition of edema in various groups were calculated and reported by percentages. Results: The results showed that the zeta potential of micelles was about −14.9 ± 0.47 mV and the average size was in range of 66.10 ± 0.34 nm. Simvastatin was encapsulated in mPEG–PCL micelles with a loading capacity of 9.63 ± 0.87% and an encapsulation efficiency of 64.20 ± 0.79%. Simvastatin and simvastatin-mPEG–PCL micelles showed significant anti-inflammatory activity in the present study. Conclusions: This study revealed that simvastatin and simvastatin/mPEG–PCL micelles both have anti-inflammatory effects and suggested that statins have potential anti-inflammatory activity along with their lipid lowering properties. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10837450
Volume :
24
Issue :
6
Database :
Complementary Index
Journal :
Pharmaceutical Development & Technology
Publication Type :
Academic Journal
Accession number :
136495937
Full Text :
https://doi.org/10.1080/10837450.2018.1556689