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Chronic hepatitis B viral infection among RA patients—a cross-sectional control study.
- Source :
- Clinical Rheumatology; May2019, Vol. 38 Issue 5, p1237-1241, 5p, 2 Charts, 1 Graph
- Publication Year :
- 2019
-
Abstract
- Background and objectives: Rheumatoid arthritis (RA) is the most common inflammatory joint disorder presenting also with extra-articular manifestations. As many other autoimmune diseases, it has been suggested that infectious diseases might contribute to its emergence. Hepatitis viruses were suggested by several reports as a trigger of RA onset. We aimed to assess the association between RA and chronic hepatitis B viral infection (HBV). Methods: Patients with RA were compared with age- and sex-matched controls regarding the proportion of chronic HBV infection in a case-control study. The chi-square and t tests were used for univariate analysis, whereas a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services. Results: There was a significantly higher proportion of chronic HBV infection in RA patients compared with controls (1.19% vs 0.63%, respectively; p < 0.001). In a multivariate logistic regression analysis, RA was significantly associated with chronic HBV infection (OR = 1.89, 95%CI 1.55–2.29, p < 0.001). Conclusions: Patients with RA have a greater proportion of chronic HBV infection than matched controls. Screening for HBV infection among RA patients may be warranted. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07703198
- Volume :
- 38
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Clinical Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 136505143
- Full Text :
- https://doi.org/10.1007/s10067-019-04448-x