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The history of the two‐signal model of lymphocyte activation: A personal perspective.
- Source :
- Scandinavian Journal of Immunology; Jun2019, Vol. 89 Issue 6, pN.PAG-N.PAG, 1p
- Publication Year :
- 2019
-
Abstract
- The first ideas leading to The Two‐Signal Model of lymphocyte activation were published 50 years ago, but the model was not realized in one sitting. I describe the three phases that led to its contemporary formulations. A motivation underlying all these models was to generate a minimal description of what is required for antigen to inactivate and activate mature lymphocytes that, at the same time, accounts for how peripheral tolerance is achieved. I suggest the two signal model has not only provided a substantiated framework for understanding how antigen interacts differently with B cells and CD8 T cells, to result in their inactivation and activation, but its postulates are pertinent to contemporary issues concerning the inactivation and activation of CD4 T cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- LYMPHOCYTE transformation
T cells
B cells
LYMPHOCYTES
Subjects
Details
- Language :
- English
- ISSN :
- 03009475
- Volume :
- 89
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 136521783
- Full Text :
- https://doi.org/10.1111/sji.12762