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Gonadal status in reproductive age women after haematopoietic stem cell transplantation for haematological malignancies.
- Source :
- Human Reproduction; Jul2003, Vol. 18 Issue 7, p1410-1416, 7p
- Publication Year :
- 2003
-
Abstract
- <bold>Background: </bold>Ovarian failure is a frequent complication occurring after haematopoietic stem cell transplantion (SCT), which is generally ascribed to radiation treatment and antiblastic alkylating agents.<bold>Methods: </bold>Ovarian morphology and function were studied in reproductive age women 12-24 months after allogeneic SCT (n = 23) received from an HLA identical sibling, or autologous SCT (n = 22). Thirteen allo-transplanted women were suffering from chronic graft-versus-host disease (cGVHD).<bold>Results: </bold>Menstrual cycles recovered in two and four women in the allo- and auto-SCT groups respectively, being associated with younger age and longer period elapsed from transplant. There was no difference in previous use of alkylating agents between allo- and auto-transplantation, while corticosteroid treatment was longer and more recent in the allo-SCT group. Significantly higher gonadotrophin levels and lower estradiol were seen in the combined group of patients than in controls. In allo-transplanted women, androgens were also significantly lower than in controls. Ovarian and uterine volumes were lower in patients than in controls, and in the allo- than in the auto-transplanted women. Within the allo-SCT group, endocrine function and ovarian and uterine volumes were significantly lower in the patients suffering from cGVHD.<bold>Conclusions: </bold>Ovarian failure in SCT recipients is likely to be caused principally by myelo-ablative treatments, but the condition of gonadal and androgen insufficiency can be worsened by an altered immunomodulation in allogeneic setting. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02681161
- Volume :
- 18
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Human Reproduction
- Publication Type :
- Academic Journal
- Accession number :
- 136631275