Fatal risk factors for cirrhosis complicated with the first upper gastrointestinal bleeding.

Objective: To explore the fatal risk factors of liver cirrhosis complicated with the first upper gastrointestinal bleeding, so as to provide reference for clinical prevention and treatment. Methods: 572 patients with cirrhosis admitted to North China University of Science and Technology and Tangshan Infectious Diseases Hospital from January 2014 to January 2018 were selected. According to whether there is concurrent upper gastrointestinal bleeding, it is divided into 163 cases of hemorrhage group and 409 cases of non-bleeding group. The patients in the hemorrhagic group were divided into case group (65 cases died of first upper gastrointestinal bleeding) and control group (98 cases died of non-first upper gastrointestinal bleeding). The general clinical data, laboratory and imaging data of the patients were analyzed. The risk factors of upper gastrointestinal bleeding in cirrhosis and the independent risk factors of the first upper gastrointestinal bleeding in cirrhosis were analyzed. Results: (1) Univariate analysis showed that: there were significant differences in Hb, PLT, CHE, ALB, TBIL, PT, left gastric vein diameter, portal vein diameter, course of cirrhosis, family history of cirrhosis, Child classification of liver function, esophagogastric varices, ascites, hepatic encephalopathy and portal vein thrombosis between hemorrhagic and non-hemorrhagic groups (P<0.05). The difference was statistically significant; (2) Multivariate logistic regression analysis showed that the diameter of left gastric vein, esophageal varices, ascites, Child C grade of liver function and portal vein thrombosis were risk factors for upper gastrointestinal bleeding in patients with cirrhosis. Left gastric vein diameter, esophagogastric varices and portal vein thrombosis are independent risk factors for first upper gastrointestinal bleeding in cirrhosis. Conclusion: Wider internal diameter of left gastric vein, severe esophagogastric varices and portal vein thrombosis are independent risk factors for fatal upper gastrointestinal bleeding in cirrhosis. [ABSTRACT FROM AUTHOR]