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Autophagy represses hepatic carcinogenesis.
- Source :
- Molecular & Cellular Oncology; 2019, Vol. 6 Issue 4, pN.PAG-N.PAG, 1p
- Publication Year :
- 2019
-
Abstract
- Hepatocyte-specific knockout of the essential autophagy gene Autophagy-related 7 (Atg7) is sufficient to cause hepatic carcinogenesis. A recent paper by Lee et al. unveils the molecular pathway accounting for hepatic hypertrophy and hyperplasia followed by malignant transformation. This pathway involves the overactivation of the transcription factor yes-associated protein (YAP), which turns out to be an autophagic substrate. Of note, the transcriptional signature activated in mouse hepatocytes lacking Atg7 resembles that found in non-alcoholic steatohepatitis (NASH), as well as in the steatohepatitic subtype of human hepatocellular carcinomas. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 23723556
- Volume :
- 6
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Molecular & Cellular Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 136746135
- Full Text :
- https://doi.org/10.1080/23723556.2019.1573080