THE DYNAMIC X-RAY OF INTESTINAL PNEUMATOSIS IN NEONATES WHO RECEIVED MULTI-MODAL ENTERAL MEDICATION REGIMEN BOTH IN TREATMENT AND PREVENTION OF NECROTIZING ENTEROCOLITIS.

Despite of history of about 200 years necrotizing enterocolitis is still remains a major concern for neonatologists, pediatric surgeons and gastroenterologists due to its high morbidity and mortality. Diagnosis is based on radiographic evidence of bowel distension, ileus, pneumatosis intestinalis and/or bowel perforation. Abdominal X-ray have been shown to be useful in helping to monitor the progression of the disease and detecting the presence of necrotizing enterocolitis. The aim of the study is to determine the effectiveness of the multi-modal 3 component necrotizing enterocolitis prophylaxis per oral scheme (Gentamicin + Nystatin + LactoG synbiotic) in complex treatment of necrotizing enterocolitis and its prevention. Newborns underwent (n=33) the digital plain-film abdominal radiographs on second day after hospital admission and administration of multi-modal 3 component enteral necrotizing enterocolitis prophylaxis scheme during period of 15th October 2018 to 5th December 2018. The digital x-ray examinations were repeated on 3rd and 5th days in dynamic. In all 9 newborns with necrotizing enterocolitis on 1st day the intestinal pneumatosis in different manifestations has been revealed by x-ray (24 hours after receive of the multi-modal 3 component enteral necrotizing enterocolitis prophylaxis scheme). On 3rd and 5th days the positive dynamic of intestinal pneumatosis was described by digital x-ray and this corresponded to a positive clinical dynamic. The results of our study shows that multi-modal 3 component necrotizing enterocolitis prophylaxis per oral scheme (Gentamicin + Nystatin + LactoG synbiotic) has a positive effect on the resolution of process of intestinal damage manifested in the form of intestinal pneumatosis in newborns with necrotizing enterocolitis. Also the multi-modal 3 component necrotizing enterocolitis prophylaxis per oral scheme has a clear effect on the prevention of necrotizing enterocolitis developmental process. [ABSTRACT FROM AUTHOR]