Long non-coding and coding RNA profiling using strand-specific RNA-seq in human hypertrophic cardiomyopathy.

Hypertrophic cardiomyopathy (HCM) represents one of the most common heritable heart diseases. However, the signalling pathways and regulatory networks underlying the pathogenesis of HCM remain largely unknown. Here, we present a strand-specific RNA-seq dataset for both coding and lncRNA profiling in myocardial tissues from 28 HCM patients and 9 healthy donors. This dataset constitutes a valuable resource for the community to examine the dysregulated coding and lncRNA genes in HCM versus normal conditions. Design Type(s) transcription profiling design • disease state design • sequence analysis objective Measurement Type(s) transcription profiling assay Technology Type(s) RNA sequencing Factor Type(s) experimental condition Sample Characteristic(s) Homo sapiens • heart Machine-accessible metadata file describing the reported data (ISA-Tab format) [ABSTRACT FROM AUTHOR]