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Downgrading disease transmission risk estimates using terminal importations.

Authors :
Fox, Spencer J.
Bellan, Steven E.
Perkins, T. Alex
Johansson, Michael A.
Meyers, Lauren Ancel
Source :
PLoS Neglected Tropical Diseases; 6/14/2019, Vol. 13 Issue 6, p1-19, 19p
Publication Year :
2019

Abstract

As emerging and re-emerging infectious arboviruses like dengue, chikungunya, and Zika threaten new populations worldwide, officials scramble to assess local severity and transmissibility, with little to no epidemiological history to draw upon. Indirect estimates of risk from vector habitat suitability maps are prone to great uncertainty, while direct estimates from epidemiological data are only possible after cases accumulate and, given environmental constraints on arbovirus transmission, cannot be widely generalized beyond the focal region. Combining these complementary methods, we use disease importation and transmission data to improve the accuracy and precision of a priori ecological risk estimates. We demonstrate this approach by estimating the spatiotemporal risks of Zika virus transmission throughout Texas, a high-risk region in the southern United States. Our estimates are, on average, 80% lower than published ecological estimates—with only six of 254 Texas counties deemed capable of sustaining a Zika epidemic—and they are consistent with the number of autochthonous cases detected in 2017. Importantly our method provides a framework for model comparison, as our mechanistic understanding of arbovirus transmission continues to improve. Real-time updating of prior risk estimates as importations and outbreaks arise can thereby provide critical, early insight into local transmission risks as emerging arboviruses expand their global reach. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19352727
Volume :
13
Issue :
6
Database :
Complementary Index
Journal :
PLoS Neglected Tropical Diseases
Publication Type :
Academic Journal
Accession number :
137007303
Full Text :
https://doi.org/10.1371/journal.pntd.0007395