Back to Search
Start Over
Clinical and Economic Impact of Adopting Noninvasive Prenatal Testing as a Primary Screening Method for Fetal Aneuploidies in the General Pregnancy Population.
- Source :
- Fetal Diagnosis & Therapy; Jul2019, Vol. 45 Issue 6, p413-423, 11p
- Publication Year :
- 2019
-
Abstract
- <bold>Objective: </bold>To evaluate the clinical and economic impact of adopting noninvasive prenatal testing (NIPT) using circulating cell-free DNA as a first-line screening method for trisomy 21, 18, and 13 in the general pregnancy population.<bold>Methods: </bold>A decision-analytical model was developed to assess the impact of adopting NIPT as a primary screening test compared to conventional screening methods. The model takes the Belgium perspective and includes only the direct medical cost of screening, diagnosis, and procedure-related complications. NIPT costs are EUR 260. Clinical outcomes and the cost per trisomy detected were assessed. Sensitivity analysis measured the impact of NIPT false-positive rate (FPR) on modelled results.<bold>Results: </bold>The cost per trisomy detected was EUR 63,016 for conventional screening versus EUR 66,633 for NIPT, with a difference of EUR 3,617. NIPT reduced unnecessary invasive tests by 94.8%, decreased procedure-related miscarriages by 90.8%, and increased trisomies detected by 29.1%. Increasing the FPR of NIPT (from < 0.01 to 1.0%) increased the average number of invasive procedures required to diagnose a trisomy from 2.2 to 4.5, respectively.<bold>Conclusion: </bold>NIPT first-line screening at a reasonable cost is cost-effective and provides better clinical outcomes. However, modelled results are dependent on the adoption of an NIPT with a low FPR. [ABSTRACT FROM AUTHOR]
- Subjects :
- MEDICAL care costs
PRENATAL diagnosis
ANEUPLOIDY
MISCARRIAGE
TRISOMY
Subjects
Details
- Language :
- English
- ISSN :
- 10153837
- Volume :
- 45
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Fetal Diagnosis & Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 137037701
- Full Text :
- https://doi.org/10.1159/000491750