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Ligand-controlled switch in diastereoselectivities: catalytic asymmetric construction of spirocyclic pyrrolidine-azetidine/oxe(thie)tane derivatives.
- Source :
- Chemical Communications; 6/28/2019, Vol. 55 Issue 51, p7346-7349, 4p
- Publication Year :
- 2019
-
Abstract
- An efficient catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides with four-membered ring-containing exocyclic alkenes has been developed, and either the exo or endo spirocyclic pyrrolidine-azetidine/oxe(thie)tane derivatives were diastereodivergently generated by employing Cu(i)/tBu-Phosferrox and a Cu(i)/N,O–ligand complex, respectively. Notably, various heteroatom-containing (N, O, S) exocyclic alkenes were found to be well-tolerated in this transformation. [ABSTRACT FROM AUTHOR]
- Subjects :
- PYRROLIDINE synthesis
YLIDES
ALKENES
CONSTRUCTION
RING formation (Chemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 55
- Issue :
- 51
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 137078593
- Full Text :
- https://doi.org/10.1039/c9cc03589c