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Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG.
- Source :
- Bone Research; 6/26/2019, Vol. 7 Issue 1, pN.PAG-N.PAG, 1p
- Publication Year :
- 2019
-
Abstract
- Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells (USCs), which were noninvasively harvested from unlimited and easily available urine, as a "factory" to obtain extracellular vesicles (USC-EVs) and demonstrated that the systemic injection of USC-EVs effectively alleviates bone loss and maintains bone strength in osteoporotic mice by enhancing osteoblastic bone formation and suppressing osteoclastic bone resorption. More importantly, the anti-osteoporotic properties of USC-EVs are not notably disrupted by the age, gender, or health condition (with or without osteoporosis) of the USC donor. Mechanistic studies determined that collagen triple-helix repeat containing 1 (CTHRC1) and osteoprotegerin (OPG) proteins are enriched in USC-EVs and required for USC-EV-induced pro-osteogenic and anti-osteoclastic effects. Our results suggest that autologous USC-EVs represent a promising novel therapeutic agent for osteoporosis by promoting osteogenesis and inhibiting osteoclastogenesis by transferring CTHRC1 and OPG. [ABSTRACT FROM AUTHOR]
- Subjects :
- STEM cells
OSTEOPOROSIS prevention
URINE
OSTEOPROTEGERIN
OSTEOCLASTOGENESIS
Subjects
Details
- Language :
- English
- ISSN :
- 20954700
- Volume :
- 7
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Bone Research
- Publication Type :
- Academic Journal
- Accession number :
- 137183436
- Full Text :
- https://doi.org/10.1038/s41413-019-0056-9