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Synthesis, characterizations, crystal structures, BSA-binding, molecular docking, and cytotoxic activities of nickel(II) and copper(II) coordination complexes with bidentate N,S-chelating ligand.
- Source :
- Journal of Coordination Chemistry; May2019, Vol. 72 Issue 10, p1715-1735, 21p, 6 Diagrams, 4 Charts, 4 Graphs
- Publication Year :
- 2019
-
Abstract
- In the present investigation, we report the synthesis and characterization of three novel nickel(II) [Ni(L)<subscript>2</subscript>] (1) and copper(II) [Cu(L)<subscript>2</subscript>] (2a) and [Cu(L)<subscript>2</subscript>] (2b) complexes, which are made through the coordination of (E)-1-(2-methoxybenzylidine)-4-phenylethiosemicarbazone (HL) as bidentate N,S-ligand. Several modern techniques including experimental electronic and fluorescence spectroscopy, single-crystal X-ray crystallography, molecular docking and BSA-binding are used to characterize the isolated coordination compounds. X-ray crystallography, FT-IR and UV–visible spectra agree with the observed crystal structures. The crystallographic and spectroscopic studies confirmed that these complexes display four-coordinate square-planar trans-[MN<subscript>2</subscript>S<subscript>2</subscript>] coordination geometry, whose central metal(II) atom lies on the center of symmetry. Complexes 1 and 2a crystallized in the orthorhombic system of the space group Pbca whereas 2b crystallized in the monoclinic system of P2<subscript>1</subscript>/c. The binding affinity of complexes towards bovine serum albumin (BSA) was determined by UV–visible and fluorescence spectrophotometric methods. The cytotoxic/antiproliferative potential of the synthesized compounds on human cell lines was also investigated by MTT assay. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00958972
- Volume :
- 72
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Journal of Coordination Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 137248671
- Full Text :
- https://doi.org/10.1080/00958972.2019.1602867