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Expansion deficiency of CAR‐T cells in patients with lymphoma and resolution by T cell purification.

Authors :
Chen, Lvzhe
Li, Shiqi
Wang, Meiling
Li, Yunyan
Xiong, Zhouxing
Zhang, Rui
Xu, Yanmin
Huang, Zixuan
Wang, Linling
Wang, Sanbin
Yang, Zhi
Qian, Cheng
Source :
British Journal of Haematology; Jul2019, Vol. 186 Issue 2, p340-343, 4p, 2 Graphs
Publication Year :
2019

Abstract

The article discusses the expansion deficiency of CAR-T cells in patients with lymphoma and resolution by T cell purification. Topics include how CD19-targeting chimeric antigen receptor (CAR)-T cells have shown impressive efficiency in the treatment of relapsed and refractory B cell malignancies and expansion failure in some patients, especially in lymphoma patients.

Subjects

Subjects :
T cells
CELLS
CD19 antigen

Details

Language :
English
ISSN :
00071048
Volume :
186
Issue :
2
Database :
Complementary Index
Journal :
British Journal of Haematology
Publication Type :
Academic Journal
Accession number :
137267040
Full Text :
https://doi.org/10.1111/bjh.15822