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Effect of maternal baboon (Papio sp.) dietary mismatch in pregnancy and lactation on post‐natal offspring early life phenotype.
- Source :
- Journal of Medical Primatology; Aug2019, Vol. 48 Issue 4, p226-235, 10p
- Publication Year :
- 2019
-
Abstract
- Background: Non‐human primate models of developmental programing by maternal mismatch between pregnancy and lactation diets are needed for translation to human programing outcomes. We present baboon offspring morphometry from birth to 3 years, and blood cortisol and adrenocorticotropin (ACTH) from 2 to 24 months. Methods: Control mothers ate chow; mismatch mothers ate 30% less than controls during pregnancy and high‐fat high‐energy diet through lactation. Results: Mismatch mothers lost weight during pregnancy. At birth, there were trends toward lower weight in mismatch offspring of both sexes (P = 0.06). From 0‐3 years, catch‐up growth occurred. Mismatch offspring male and female body weight increased faster than controls (P < 0.001). Mismatch female offspring showed greater increase in BMI (P < 0.001) and abdominal circumference (P = 0.008) vs controls. ACTH and cortisol slopes from 2 to 24 months of age were similar between groups in both sexes. Cortisol and ACTH increased after weaning in all groups. Conclusions: Mismatch produces sexually dimorphic post‐natal growth phenotypes. [ABSTRACT FROM AUTHOR]
- Subjects :
- PREGNANCY
BABOONS
HIGH-fat diet
LACTATION
ADRENOCORTICOTROPIC hormone
WEIGHT loss
Subjects
Details
- Language :
- English
- ISSN :
- 00472565
- Volume :
- 48
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Medical Primatology
- Publication Type :
- Academic Journal
- Accession number :
- 137286876
- Full Text :
- https://doi.org/10.1111/jmp.12415