Back to Search
Start Over
Dependence of CD8 T Cell Response upon Antigen Load During Primary Infection: Analysis of Data from Yellow Fever Vaccination.
- Source :
- Bulletin of Mathematical Biology; Jul2019, Vol. 81 Issue 7, p2553-2568, 16p
- Publication Year :
- 2019
-
Abstract
- A major question in immunology is what role antigen load plays in determining the size of the CD8 immune response. Is the amount of antigen important during recruitment, proliferation, and/or memory formation? Animal studies have shown that antigen is only strictly required early during activation of T cells, but the importance of antigen at later timepoints is unclear. Using data from 24 volunteers infected with the yellow fever vaccine virus (YFV), we analyzed the dependence of T cell proliferation upon viral load. We found that volunteers with high viral load initially have greater T cell responses, but by 28 days post-vaccination those with lower viral load are able to 'catch-up.' Using differential equation modeling we show that this pattern is consistent with viral load only affecting recruitment (i.e., programmed proliferation) as opposed to affecting recruitment and proliferation (i.e., antigen-dependent proliferation). A quantitative understanding of the dependence of T cell dynamics on antigen load will be of use to modelers studying not only vaccination, but also cancer immunology and autoimmune disorders. [ABSTRACT FROM AUTHOR]
- Subjects :
- YELLOW fever
T cells
INFECTION
DATA analysis
ANTIGENS
Subjects
Details
- Language :
- English
- ISSN :
- 00928240
- Volume :
- 81
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Bulletin of Mathematical Biology
- Publication Type :
- Academic Journal
- Accession number :
- 137363046
- Full Text :
- https://doi.org/10.1007/s11538-019-00618-9