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The treatment outcomes in IgG4‐related orbital disease: a systematic review of the literature.
- Source :
- Acta Ophthalmologica (1755375X); Aug2019, Vol. 97 Issue 5, p451-459, 9p
- Publication Year :
- 2019
-
Abstract
- IgG4‐related disease (IgG4‐RD) is an immune‐mediated systemic fibro inflammatory disease. Treatment of IgG4‐related orbital disease (IgG4‐ROD) is often indicated to relieve the symptoms and to prevent complications. For IgG4‐ROD, no international formal treatment guidelines are available and the optimal treatment strategy is uncertain. In this systematic review, we describe the efficacy of conventional and biologic disease‐modifying antirheumatic drugs (DMARDs) in IgG4‐ROD. A systematic search of Embase, Medline, Web‐of‐Science, PubMed publisher, Cochrane and Google Scholar was performed for treatment outcomes in IgG4‐ROD. Relevant articles on treatment of IgG4‐ROD were retrieved to last date of inclusion 3 January 2018. The following inclusion criteria were used: articles in English or English translation, studies evaluating the use of DMARDs (conventional and biologic) in the treatment of IgG4‐ROD. Meta‐analysis and review articles were excluded. A final selection after full‐text evaluation was made by independent reviewers, based on treatment of IgG4‐ROD with DMARDs and the availability of treatment outcomes. With this systematic review, we identified 35 studies and case reports/series on IgG4‐ROD, describing 95 patients, treated with conventional and/or biologic DMARDs. The success of conventional DMARDs varies between 36% and 75% in patients with IgG4‐ROD, while rituximab is successful in the majority (93%) of the patients. Based on this systematic review, rituximab is the most effective DMARD in IgG4‐ROD, while the efficacy of conventional DMARDs is limited. We propose early initiation of rituximab in case of refractory and organ‐ or life‐threatening disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- META-analysis
TREATMENT effectiveness
THERAPEUTICS
ORBITAL diseases
RITUXIMAB
Subjects
Details
- Language :
- English
- ISSN :
- 1755375X
- Volume :
- 97
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Acta Ophthalmologica (1755375X)
- Publication Type :
- Academic Journal
- Accession number :
- 137375086
- Full Text :
- https://doi.org/10.1111/aos.14048