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Correlates of T50 and relationships with bone mineral density in community-living older men: the osteoporotic fractures in men (MrOS) study.
- Source :
- Osteoporosis International; Jul2019, Vol. 30 Issue 7, p1529-1531, 3p, 2 Charts
- Publication Year :
- 2019
-
Abstract
- Purpose: T<subscript>50</subscript> is a novel serum-based marker that assesses the propensity of calcification in serum. Shorter T<subscript>50</subscript> indicates greater propensity to calcify and it has been associated to cardiovascular disease (CVD) and mortality among patients with kidney disease. In the general population, neither the correlates of T<subscript>50</subscript> nor the relationships of T<subscript>50</subscript> with bone mineral density (BMD) are known. Methods: We performed a nested cross-sectional study selecting 150 individuals at random among participants from the Osteoporotic Fractures in Men (MrOS) Study, a study of community-living older men. We categorized individuals into tertiles of T<subscript>50</subscript> and compared demographics and disease indicators across tertiles. We utilized linear regression to evaluate the cross-sectional association between T<subscript>50</subscript> and hip and spine BMD in multivariable models. Results: Older age was associated with shorter T<subscript>50</subscript>. Kidney function tended to be lower in those with shorter T<subscript>50</subscript> and the prevalence of CVD and peripheral arterial disease in those with shorter T<subscript>50</subscript>, albeit these findings did not achieve statistical significance. We found no statistically significant associations between T<subscript>50</subscript> and total hip or total spine BMD in either unadjusted or multivariable adjusted models. Conclusions: T<subscript>50</subscript>, a novel indicator of serum calcification propensity, is not associated with BMD in community-living older men. Future larger studies should determine if T<subscript>50</subscript> may give insights to CVD in the general population above and beyond traditional risk factors. [ABSTRACT FROM AUTHOR]
- Subjects :
- KIDNEY physiology
OSTEOPOROSIS diagnosis
DIAGNOSIS of bone fractures
ELDER care
BIOMARKERS
CARDIOVASCULAR diseases risk factors
HIP joint
MEN'S health
PERIPHERAL vascular diseases
REGRESSION analysis
SPINE
BONE density
INDEPENDENT living
DISEASE prevalence
CROSS-sectional method
STATISTICAL models
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 0937941X
- Volume :
- 30
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Osteoporosis International
- Publication Type :
- Academic Journal
- Accession number :
- 137398876
- Full Text :
- https://doi.org/10.1007/s00198-019-04925-8