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CDR2L Is the Major Yo Antibody Target in Paraneoplastic Cerebellar Degeneration.
- Source :
- Annals of Neurology; Aug2019, Vol. 86 Issue 2, p316-321, 6p
- Publication Year :
- 2019
-
Abstract
- The pathogenesis of Yo-mediated paraneoplastic cerebellar degeneration (PCD) is unclear. We applied cerebrospinal fluid and serum from PCD patients as well as CDR2 and CDR2L antibodies to neuronal tissue, cancer cell lines, and cells transfected with recombinant CDR2 and CDR2L to elucidate which is the major antigen of Yo antibodies. We found that Yo antibodies bound endogenous CDR2L, but not endogenous CDR2. However, Yo antibodies can bind the recombinant CDR2 protein used in routine clinical testing for these antibodies. Because Yo antibodies only bind endogenous CDR2L, we conclude that CDR2L is the major antigen of Yo antibodies in PCD. ANN NEUROL 2019;86:316-321. [ABSTRACT FROM AUTHOR]
- Subjects :
- CEREBELLUM degeneration
RECOMBINANT proteins
CEREBROSPINAL fluid
IMMUNOGLOBULINS
CANCER cells
AUTOANTIBODIES
RESEARCH
PARANEOPLASTIC syndromes
NERVE tissue proteins
ANIMAL experimentation
RESEARCH methodology
EVALUATION research
MEDICAL cooperation
CEREBELLUM
RATS
COMPARATIVE studies
EPITHELIAL cells
ANTIGENS
Subjects
Details
- Language :
- English
- ISSN :
- 03645134
- Volume :
- 86
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Annals of Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 137436304
- Full Text :
- https://doi.org/10.1002/ana.25511