Back to Search
Start Over
Factors predicting peripheral blood progenitor cell mobilization in healthy donors in the era of related alternative donors: Experience from a single center.
- Source :
- Journal of Clinical Apheresis; Aug2019, Vol. 34 Issue 4, p373-380, 8p
- Publication Year :
- 2019
-
Abstract
- Background: Poor mobilization results are unexpected after G‐CSF‐induced peripheral blood stem cell collection in healthy donors. However, 2%‐5% of the donors are poor mobilizers. Factors predicting CD34+‐cell yield after mobilization in related alternative donors are still poorly known. Patients and methods: Baseline characteristics and efficacy results of G‐CSF induced mobilization of 159 adult healthy donors in our institution from 2008 to 2016 were retrospectively analyzed. All donors received 10 μg/kg of G‐CSF once a day subcutaneously for 4 days. Leukapheresis started on the 5th day of G‐CSF treatment. Donors were classified as poor mobilizers if they had less than 20 000 CD34 + cell/mL peripheral blood count in the 5th day of G‐CSF treatment or if they needed three or more leukapheresis for graft collection. Results: Age, weight, and platelet count before and after mobilization were significantly different between poor and good mobilizers. Poor mobilizers (n = 16) were older (50.6 vs 41.7 years, P = 0.002), weight lower (64 vs 75 kg, P = 0.00) and showed a lower platelet count before (199.5 vs 219.0 × 109/L, P = 0.03) and after (192.5 vs 206 × 109/L, P = 0.019) mobilization. In the multivariate analysis only the 30% of the variability of mobilization was explained by the model (sensitivity 80%, specificity 70%). Conclusion: In this cohort of healthy donors in a single institution, older age, less weight, and lower platelet count was associated with poorer mobilization. With clinical and analytic factors it is not possible to predict more than 30% of the variability. Further studies are needed to investigate new variables. [ABSTRACT FROM AUTHOR]
- Subjects :
- PROGENITOR cells
BLOOD cells
PLATELET count
STEM cells
LEUKAPHERESIS
Subjects
Details
- Language :
- English
- ISSN :
- 07332459
- Volume :
- 34
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Apheresis
- Publication Type :
- Academic Journal
- Accession number :
- 137586453
- Full Text :
- https://doi.org/10.1002/jca.21685