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Protective effects of a novel water-soluble biphenyl compound WLP-S-14 against acute-on-chronic liver failure in rats.
- Source :
- Journal of Asian Natural Products Research; Sep2019, Vol. 21 Issue 9, p928-938, 11p
- Publication Year :
- 2019
-
Abstract
- This study investigated the therapeutic effects of a water-soluble biphenyl compound, WLP-S-14, in acute-on-chronic liver failure (ACLF). Wistar rats were injected intraperitoneally with porcine serum twice a week for 8 weeks prior to administration of 600 mg/kg D-galactosamine and 50 μg/kg lipopolysaccharide to induce ACLF. Study groups were treated intravenously with saline or with 100 or 200 mg/kg WLP-S-14. WLP-S-14 ameliorated ACLF with significant reductions in the mortality rate and transaminase levels, indicating improved liver function. The mechanism underlying these effects may involve decreased levels of tumor necrosis factor-α and interleukin-6, with associated inhibition of apoptotic pathways. [ABSTRACT FROM AUTHOR]
- Subjects :
- AMINOTRANSFERASES
ANIMAL experimentation
APOPTOSIS
BIOMARKERS
BIOCHEMISTRY
BIOLOGICAL models
BIPHENYL compounds
BLOOD coagulation
CARBOHYDRATES
HISTOLOGICAL techniques
INTERLEUKINS
LIVER
LIVER failure
MOLECULAR structure
MORTALITY
PHYSIOLOGIC salines
RATS
SERUM
SURVIVAL
TUMOR necrosis factors
WESTERN immunoblotting
LIPOPOLYSACCHARIDES
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 21
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 137680029
- Full Text :
- https://doi.org/10.1080/10286020.2019.1585822