Liposomal Vitamin D3 as an Anti-aging Agent for the Skin.

Vitamin D₃ is an effective skin protective substance to prevent photoaging. Liposomes were used as a carrier to deliver vitamin D₃ to improve the stability and to enhance the treatment effect of vitamin D₃. The stability of vitamin D₃ liposomes, average cumulative penetration, and retention of vitamin D₃ in the skin were then evaluated and compared with free vitamin D₃. Finally, the treatment effect of vitamin D₃ liposomes in a rat photoaging model was appraised and Haematoxylin-Eosin (H&E) staining was used to assess the histology changes of the skin after vitamin D₃ liposome treatment. The results indicated that liposomes could significantly improve the stability of vitamin D₃. The average skin retention of vitamin D₃ liposomes was 1.65 times that of the vitamin D₃ solution. Vitamin D₃ liposomes could repair the surface morphology of skin in the photoaging model and promote the production of new collagen fibers. Vitamin D₃ liposomes as a potential skin care agent could significantly improve skin appearance and repair damage in the histology of photoaging. [ABSTRACT FROM AUTHOR]