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Preparation and Characterization of Oxidized Inulin Hydrogel for Controlled Drug Delivery.

Authors :
Afinjuomo, Franklin
Fouladian, Paris
Parikh, Ankit
Barclay, Thomas G.
Song, Yunmei
Garg, Sanjay
Source :
Pharmaceutics; Jul2019, Vol. 11 Issue 7, p356-356, 1p
Publication Year :
2019

Abstract

Inulin-based hydrogels are useful carriers for the delivery of drugs in the colon-targeted system and in other biomedical applications. In this project, inulin hydrogels were fabricated by crosslinking oxidized inulin with adipic acid dihydrazide (AAD) without the use of a catalyst or initiator. The physicochemical properties of the obtained hydrogels were further characterized using different techniques, such as swelling experiments, in vitro drug release, degradation, and biocompatibility tests. The crosslinking was confirmed with Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), and differential scanning calorimetry (DSC). In vitro releases of 5-fluorouracil (5FU) from the various inulin hydrogels was enhanced in acidic conditions (pH 5) compared with physiological pH (pH 7.4). In addition, blank gels did not show any appreciable cytotoxicity, whereas 5FU-loaded hydrogels demonstrated efficacy against HCT116 colon cancer cells, which further confirms the potential use of these delivery platforms for direct targeting of 5-FU to the colon. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19994923
Volume :
11
Issue :
7
Database :
Complementary Index
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
137798813
Full Text :
https://doi.org/10.3390/pharmaceutics11070356