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Efficacy and safety of one-day offline extracorporeal photopheresis schedule processing one total blood volume for treating patients with graft-versus-host disease.

Authors :
Cid, Joan
Carbassé, Gloria
Suárez‐Lledó, María
Moreno, David F.
Martínez, Carmen
Gutiérrez‐García, Gonzalo
Fernández‐Avilés, Francesc
Rosiñol, Laura
Giavedoni, Priscila
Mascaró, José M.
Agustí, Carles
Marín, Pedro
Rovira, Montserrat
Urbano‐Ispizua, Álvaro
Lozano, Miquel
Suárez-Lledó, María
Gutiérrez-García, Gonzalo
Fernández-Avilés, Francesc
Mascaró, José M Jr
Urbano-Ispizua, Álvaro
Source :
Transfusion; Aug2019, Vol. 59 Issue 8, p2636-2642, 7p, 5 Charts, 1 Graph
Publication Year :
2019

Abstract

<bold>Background: </bold>Extracorporeal photopheresis (ECP) has been increasingly used as a second-line therapy for graft-versus-host disease (GVHD) but there is no consensus regarding the best therapeutic schedule.<bold>Study Design and Methods: </bold>Our offline ECP schedule for treating patients with GVHD was retrospectively reviewed. Patients with acute GVHD were treated on 2 days per week for the first 2 weeks, followed by 1 day per week for 2 more weeks. After the first month of treatment, patients received treatment 1 day every 2 weeks for a minimum of 16 ECP procedures. Patients with chronic GVHD were treated on 1 day per week for 4 weeks followed by 1 day every 2 weeks for a minimum of 14 ECP procedures.<bold>Results: </bold>Our series comprises 21 (45%) patients with acute GVHD and 26 (55%) patients with chronic GVHD who received 667 ECP procedures. A median (interquartile range [IQR]) of 1.0 (1.0-1.12) total blood volume was processed. Patients with acute and chronic GVHD received ECP procedures during a median of 49 (IQR, 14-103) and 180 (IQR, 111-274) days, respectively. Mild citrate-induced symptoms were present in 98 (46%) and 232 (51%) procedures in patients with acute and chronic GVHD, respectively. Overall response rate (ORR) and overall survival (OS) were 57 and 38% (95% confidence interval [CI], 17%-59%), respectively, for patients with acute GVHD. For patients with chronic GVHD, ORR and OS were 77 and 61% (95% CI, 18%-87%), respectively.<bold>Conclusion: </bold>Our new offline ECP schedule for treating patients with acute and chronic GVHD was efficacious and safe. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00411132
Volume :
59
Issue :
8
Database :
Complementary Index
Journal :
Transfusion
Publication Type :
Academic Journal
Accession number :
137845736
Full Text :
https://doi.org/10.1111/trf.15384