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Gene Expression Profiling Reveals that PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice.
- Source :
- International Journal of Molecular Sciences; Aug2019, Vol. 20 Issue 15, p3767-3767, 1p, 4 Graphs
- Publication Year :
- 2019
-
Abstract
- The article examines the transcriptomic signature of pregnane X receptor (PXR) activation in the liver of adult wild-type vs. Pxr -/- C57BI6/J male mice treated with the rodent specific ligand pregnenolone 16-carbonitrile. Topics covered include potential metabolic dysregulations induced upon PXR activation, effect of PXR activation on physiological parameters and liver lipids, and the effects of PXR activation on the hepatic transcriptome.
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 20
- Issue :
- 15
- Database :
- Complementary Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 137964959
- Full Text :
- https://doi.org/10.3390/ijms20153767