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A water-soluble AIE-active polyvalent glycocluster: design, synthesis and studies on carbohydrate–lectin interactions for visualization of Siglec distributions in living cell membranes.
- Source :
- Chemical Communications; 8/25/2019, Vol. 55 Issue 66, p9869-9872, 4p
- Publication Year :
- 2019
-
Abstract
- In this work, we designed and synthesized an aggregation-induced emission (AIE)-active tetraphenylethene-decorated pseudo-trisialic acid (TPE3S) and validated its high affinity for Siglecs using microscale thermophoresis techniques. TPE3S was a unique binding-on fluorescent trivalent sialocluster which was successfully utilized for the visualization of Siglecs expressed on the surface of mammalian cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- CELL membranes
VISUALIZATION
LECTINS
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 55
- Issue :
- 66
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 138030580
- Full Text :
- https://doi.org/10.1039/c9cc05008f