Back to Search Start Over

Balance impairment in pediatric charcot-marie-tooth disease.

Authors :
Estilow, Timothy
Glanzman, Allan M.
Burns, Joshua
Harrington, Ann
Cornett, Kayla
Menezes, Manoj P.
Shy, Rosemary
Moroni, Isabella
Pagliano, Emanuela
Pareyson, Davide
Bhandari, Trupti
Muntoni, Francesco
LaurĂ¡, Matilde
Reilly, Mary M.
Finkel, Richard S.
Eichinger, Kate J.
Herrmann, David N.
Troutman, Gregory
Bray, Paula
Halaki, Mark
Source :
Muscle & Nerve; Sep2019, Vol. 60 Issue 3, p242-249, 8p
Publication Year :
2019

Abstract

<bold>Introduction: </bold>Balance impairment contributes to gait dysfunction, falls, and reduced quality of life in adults with Charcot-Marie-Tooth disease (CMT) but has been minimally examined in pediatric CMT.<bold>Methods: </bold>The CMT Pediatric Scale (CMTPedS) was administered to 520 children with CMT. Associations between balance function (Bruininks-Oseretsky Test of Motor Proficiency [BOT-2]) and sensorimotor and gait impairments were investigated.<bold>Results: </bold>Daily trips/falls were reported by 42.3% of participants. Balance (BOT-2) varied by CMT subtype, was impaired in 42% of 4-year-olds, and declined with age (P < 0.001). Vibration (P < 0.001), pinprick (P < 0.004), ankle dorsiflexion strength (P < 0.001), and foot alignment (P < 0.004) were associated with BOT-2 balance (adjusted R2 = 0.28). The visual dependence of balance increased with age.<bold>Discussion: </bold>Balance impairment occurs from a young age in children with CMT. Balance intervention studies are required in pediatric CMT and should consider the degree of sensorimotor impairment, foot malalignment, and visual dependence. Muscle Nerve, 2019. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0148639X
Volume :
60
Issue :
3
Database :
Complementary Index
Journal :
Muscle & Nerve
Publication Type :
Academic Journal
Accession number :
138052101
Full Text :
https://doi.org/10.1002/mus.26500