Back to Search
Start Over
Transcriptional signature of human proinflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis.
- Source :
- Nature Communications; 11/17/2017, Vol. 8 Issue 1, p1-14, 14p
- Publication Year :
- 2017
-
Abstract
- We have previously reported the molecular signature of murine pathogenic T<subscript>H</subscript>17 cells that induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that human peripheral blood IFN-β+IL-17+ (T<subscript>H</subscript>1/17) and IFN-β.IL-17+ (T<subscript>H</subscript>17) CD4+ T cells display distinct transcriptional profiles in high-throughput transcription analyses. Compared to T<subscript>H</subscript>17 cells, T<subscript>H</subscript>1/17 cells have gene signatures with marked similarity to mouse pathogenic TH17 cells. Assessing 15 representative signature genes in patients with multiple sclerosis, we find that T<subscript>H</subscript>1/17 cells have elevated expression of CXCR3 and reduced expression of IFNG, CCL3, CLL4, GZMB, and IL10 compared to healthy controls. Moreover, higher expression of IL10 in T <subscript>H</subscript>17 cells is found in clinically stable vs. active patients. Our results define the molecular signature of human pro-inflammatory TH17 cells, which can be used to both identify pathogenic TH17 cells and to measure the effect of treatment on TH17 cells in human autoimmune diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- T helper cells
MULTIPLE sclerosis
GENE expression
T cells
CELLS
NATALIZUMAB
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- 138053255
- Full Text :
- https://doi.org/10.1038/s41467-017-01571-8