Enantioselective Assembly of Tricyclic Tetrahydroquinoline Derivatives.

A three‐step synthetic route towards enantioenriched tricyclic tetrahydroquinoline derivatives has been investigated. The first step involved the assembly of 4‐amino‐tetrahydroquinoline core through the asymmetric three‐component Povarov reaction of benzyl (E)‐prop‐1‐en‐1‐ylcarbamate and p‐anisidine with aliphatic aldehydes of various length bearing protected hydroxyl group. The alcohol was then deprotected and employed in an intramolecular reaction with a secondary amine of tetrahydroquinoline moiety producing desired tricyclic scaffolds. [ABSTRACT FROM AUTHOR]