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Novel voltammetric investigation of dipyridamole at a disposable pencil graphite electrode.
- Source :
- Turkish Journal of Chemistry; 2019, Vol. 43 Issue 4, p1109-1122, 14p
- Publication Year :
- 2019
-
Abstract
- The present paper describes the voltammetric analysis of dipyridamole (DIP) at a cheap, disposable pencil graphite electrode (PGE). The working conditions were optimized with regard to the electrode material and the supporting electrolyte. Cyclic voltammetric investigations emphasized that DIP is irreversibly oxidized at the PGE. The electrode process is pH-dependent and controlled by both diffusion and adsorption. For DIP quantitative determination a differential pulse voltammetric (DPV) method in phosphate buffer solution pH 7.00 was developed. DIP's oxidation peak current varied linearly with the analyte concentration, presenting two linear ranges, namely 5.00 x 10<superscript>-7</superscript> -2.50 × 10<superscript>-5</superscript> M and 2.50 × 10<superscript>-5</superscript> -2.50 × 10<superscript>-4</superscript> M, with detection and quantification limits of 1.21 × 10-7 M and 4.03 × 10<superscript>-7</superscript> M DIP, respectively. The newly developed DPV method using the inexpensive, disposable PGE was successfully applied for the simple and rapid determination of DIP from pharmaceutical formulations. [ABSTRACT FROM AUTHOR]
- Subjects :
- GRAPHITE
ELECTRODES
VOLTAMMETRY
BUFFER solutions
PENCILS
DETECTION limit
Subjects
Details
- Language :
- English
- ISSN :
- 13000527
- Volume :
- 43
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Turkish Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 138267776
- Full Text :
- https://doi.org/10.3906/kim-1903-64