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Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; 8/27/2019, Vol. 116 Issue 35, p17444-17449, 6p
- Publication Year :
- 2019
-
Abstract
- Trauma hemorrhage is a leading cause of death and disability worldwide. Platelets are fundamental to primary hemostasis, but become profoundly dysfunctional in critically injured patients by an unknown mechanism, contributing to an acute coagulopathy which exacerbates bleeding and increases mortality. The objective of this study was to elucidate the mechanism of platelet dysfunction in critically injured patients. We found that circulating platelets are transformed into procoagulant balloons within minutes of injury, accompanied by the release of large numbers of activated microparticles which coat leukocytes. Ballooning platelets were decorated with histone H4, a damage-associated molecular pattern released in massive quantities after severe injury, and exposure of healthy platelets to histone H4 recapitulated the changes in platelet structure and function observed in trauma patients. This is a report of platelet ballooning in human disease and of a previously unrecognized mechanism by which platelets contribute to the innate response to tissue damage. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEMORRHAGE
CAUSES of death
HEMOSTASIS
HISTONES
BLOOD platelets
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 116
- Issue :
- 35
- Database :
- Complementary Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 138362729
- Full Text :
- https://doi.org/10.1073/pnas.1904978116