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Sophisticated specificity in the innate immune response.
- Source :
- Immunology; Oct2019, Vol. 158 Issue 2, p61-62, 2p
- Publication Year :
- 2019
-
Abstract
- Summary: Immunologists are sometimes guilty of describing the innate immune response as 'nonāspecific'. What we really mean is that the pattern recognition receptors of innate immune cells are not able to recombine and mutate to bind the spectacular range of molecular patterns that can be recognised by B and T cells. So, while it may be accurate to describe the innate immune response as less specific than adaptive immunity, even this belies the emerging complexity of the receptors and receptor complexes that control inflammatory responses. This complexity is necessary to recognise danger, and therefore successfully initiate proportionate inflammatory responses to cellular damage or against potential pathogens. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNE response
PATTERN perception receptors
B cells
T cells
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 158
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 138593755
- Full Text :
- https://doi.org/10.1111/imm.13112