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Indirect Medium Spiny Neurons in the Dorsomedial Striatum Regulate Ethanol-Containing Conditioned Reward Seeking.
- Source :
- Journal of Neuroscience; 9/4/2019, Vol. 39 Issue 36, p7206-7217, 12p
- Publication Year :
- 2019
-
Abstract
- Adenosine 2A receptor (A<subscript>2A</subscript>R)-containing indirect medium spiny neurons (iMSNs) in the dorsomedial striatum (DMS) contribute to reward-seeking behaviors. However, those roles for ethanol-seeking behaviors remain unknown. To investigate ethanol-seeking behaviors, we used an ethanol-containing reward (10% ethanol and 10% sucrose solution; 10E10S). Upon conditioning with 10E10S, mice that initially only preferred 10% sucrose, not 10E10S, showed a stronger preference for 10E10S. Then, we investigated whether the manipulation of the DMS-external globus pallidus (GPe) iMSNs circuit alters the ethanol-containing reward (10E10S) seeking behaviors using the combination of pharmacologic and optogenetic approaches. DMS A<subscript>2A</subscript>R activation dampened operant conditioning-induced ethanolcontaining reward, whereas A<subscript>2A</subscript>R antagonist abolished the effects of the A<subscript>2A</subscript>R agonist and restored ethanol-containing reward-seeking. Moreover, pre-ethanol exposure potentiated the A<subscript>2A</subscript>R-dependent reward-seeking. Interestingly, mice exhibiting ethanol-containing reward-seeking showed the reduction of the DMS iMSNs activity, suggesting that disinhibiting iMSNs decreases reward-seeking behaviors. In addition, we found that A<subscript>2A</subscript>R activation reversed iMSNs neural activity in the DMS. Similarly, optogenetic stimulation of the DMS-GPe iMSNs reduced ethanol-containing reward-seeking, whereas optogenetic inhibition of the DMS-GPe iMSNs reversed this change. Together, our study demonstrates that DMS A<subscript>2A</subscript>R and iMSNs regulate ethanol-containing reward-seeking behaviors. [ABSTRACT FROM AUTHOR]
- Subjects :
- GLOBUS pallidus
NEURONS
SUCROSE
ADENOSINES
Subjects
Details
- Language :
- English
- ISSN :
- 02706474
- Volume :
- 39
- Issue :
- 36
- Database :
- Complementary Index
- Journal :
- Journal of Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 138600430
- Full Text :
- https://doi.org/10.1523/jneurosci.0876-19.2019