Editorial: Transcriptional Regulation of Glucose Metabolism: Gaps and Controversies.

Keywords: glucose homeostasis; gene transcription; insulin resistance; insulin signaling; microRNAs It is interesting to note that mice with a partial functional loss of Prep1 have smaller pancreatic islets and reduced insulin secretion on one hand, while, on the other, they show higher insulin sensitivity in peripheral tissues, and exhibit protection from both streptozotocin-induced diabetes and diet-induced steatohepatitis. The authors also describe the association between miRNAs and metabolism, by evaluating the effects of these small mRNA molecules on insulin signaling, on glucose uptake and on the mitochondrial oxidative metabolism. Glucose homeostasis, gene transcription, insulin resistance, insulin signaling, microRNAs. [Extracted from the article]