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SERUM ENDOCAN LEVEL IN DIABETES MELLITUS OF PATIENTS WITH CIRRHOSIS AND RISK OF SUBSEQUENT DEVELOPMENT OF SPONTANEOUS BACTERIAL PERITONITIS.

Authors :
ZUWALA-JAGIELLO, J.
PAZGAN-SIMON, M.
SIMON, K.
KUKLA, M.
MURAWSKA-CIALOWICZ, E.
GRZEBYK, E.
Source :
Journal of Physiology & Pharmacology; Jun2019, Vol. 70 Issue 3, p1-7, 7p
Publication Year :
2019

Abstract

The presence of type 2 diabetes mellitus (DM) in patients with cirrhosis is associated with an increased risk of spontaneous bacterial peritonitis (SBP) which may represent an increased susceptibility to infections. Endocan is a key player in the regulation of inflammatory disorders, and a biomarker in bacteremia and sepsis. To investigate the association between both endocan and DM, and developing SBP, we conducted a retrospective cohort study. Three hundred and thirty patients (179 men, 151 women; mean age 61.0 ± 8.5 years) who were treated for liver cirrhosis were studied between January 2007 and December 2016. Univariate and multivariate analyses using age, type 2 diabetes mellitus, severity of cirrhosis (Child-Pugh or MELD score), platelet count, serum proinflammatory cytokines, procalcitonin, C-reactive protein, and endocan level were conducted to identify factors related to the development of SBP. Among 330 patients with the median follow-up of 6.0 years, the cumulative incidence of SBP at 5 years was 28.6%. On multivariate analysis, a high serum endocan level and DM were independent and significant risk factors for SBP development (hazard ratio (HR) 1.634 (95% CI: 1.012 - 2.638; P = 0.047) and 2.482 (95% CI: 1.134 - 5.412; P = 0.023), respectively). Furthermore, the cumulative incidence rate of SBP in cirrhotic patients with high endocan levels was significantly greater than that in patients with low endocan levels (P = 0.035; log-rank test). Endocan is an independent predictor of SBP development in patients with cirrhosis. Cirrhotic patients with type 2 diabetes mellitus who have a higher endocan levels should be monitored carefully for the development of spontaneous bacterial peritonitis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08675910
Volume :
70
Issue :
3
Database :
Complementary Index
Journal :
Journal of Physiology & Pharmacology
Publication Type :
Academic Journal
Accession number :
138784550
Full Text :
https://doi.org/10.26402/jpp.2019.3.06