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Comparing electrical stimulation and tacrolimus (FK506) to enhance treating nerve injuries.
- Source :
- Muscle & Nerve; Nov2019, Vol. 60 Issue 5, p629-636, 8p
- Publication Year :
- 2019
-
Abstract
- <bold>Introduction: </bold>Neuroenhancing therapies are desired because repair of nerve injuries can fail to achieve recovery. We compared two neuroenhancing therapies, electrical stimulation (ES) and systemic tacrolimus (FK506), for their capabilities to enhance regeneration in the context of a rat model.<bold>Methods: </bold>Rats were randomized to four groups: ES 0.5 mA, ES 2.0 mA, FK506, and repair alone. All groups underwent tibial nerve transection and repair, and outcomes were assessed by using twice per week walking track analysis, cold allodynia response, relative muscle mass, and nerve histology.<bold>Results: </bold>Electrical stimulation and FK506 groups demonstrated improved functional recovery and myelinated axon counts distal to the repair compared with repair alone. Electrical stimulation provided improvements in nerve regeneration that were not different from optimized FK506 systemic administration.<bold>Discussion: </bold>Providing ES after nerve repair improved regeneration and recovery in rats, with minimal differences in therapeutic efficacy to FK506, further demonstrating its clinical potential to improve management of nerve injuries. [ABSTRACT FROM AUTHOR]
- Subjects :
- PERIPHERAL nerve injuries
TIBIAL nerve surgery
TIBIAL nerve injuries
ANIMAL experimentation
COMPARATIVE studies
CONVALESCENCE
ELECTRIC stimulation
TACROLIMUS
IMMUNOSUPPRESSIVE agents
RESEARCH methodology
MEDICAL cooperation
NERVOUS system regeneration
NEUROSURGERY
RATS
RESEARCH
RESEARCH funding
TIBIAL nerve
EVALUATION research
SKELETAL muscle
PHARMACODYNAMICS
INNERVATION
Subjects
Details
- Language :
- English
- ISSN :
- 0148639X
- Volume :
- 60
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Muscle & Nerve
- Publication Type :
- Academic Journal
- Accession number :
- 139102269
- Full Text :
- https://doi.org/10.1002/mus.26659