Mina53 regulates the differentiation and proliferation of leukemia cells.

The mRNA levels of p21, which regulates the cell cycle progression and cell proliferation, were upregulated by almost twofold in both HL-60 cells and K562 cells. ATRA is known to induce cell differentiation and inhibit cell proliferation in leukemia cells.[5] Consistently, we observed an obvious cell differentiation and a significant reduction in cell proliferation when treating HL-60 cells with ATRA (Figure A,B). [Extracted from the article]