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Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis.
- Source :
- Chemical Communications; 11/14/2019, Vol. 55 Issue 88, p13267-13270, 4p
- Publication Year :
- 2019
-
Abstract
- Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential. [ABSTRACT FROM AUTHOR]
- Subjects :
- PROSTATE cancer
IMAGING of cancer
MONOAMINE oxidase
METASTASIS
CELL growth
OXIDASES
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 55
- Issue :
- 88
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 139408668
- Full Text :
- https://doi.org/10.1039/c9cc07009e